Journal: Drug Testing and Analysis
Article Title: High‐throughput liquid chromatography‐vacuum differential mobility spectrometry‐mass spectrometry for the analysis of isomeric drugs of abuse in human urine
doi: 10.1002/dta.3778
Figure Lengend Snippet: Dispersion plots (CV vs. SV) for the isomeric pairs of drugs of abuse (m/z 290) BZE/NCOC, (m/z 250) ODT/NDT, and (m/z 315) THC/CBD. (a) Infusion at 8 μL/min and in (b–f) flow injection analysis at flow rate 50 μL/min with 5% isopropanol, 20% and 80% methanol, and acetonitrile. Data were acquired in SIM mode, and the vDMS was used in scan mode (SV ramp from 0 to 900 V and CV stepped by 0.2 V).
Article Snippet: Cocaine (COC), benzoylecgonine (BZE), norcocaine (NCOC), ecgonine methyl ester (EME), cocaethylene (ECOC), tramadol (TRA), O ‐desmethyl‐cis‐tramadol (ODT), N ‐desmethyl‐cis‐tramadol (NDT), Δ 9 ‐tetrahydrocannabinol (THC), Δ 9 ‐tetrahydrocannabidiol (CBD), 11‐hydroxy‐Δ 9 ‐tetrahydrocannabinol (THC‐OH), 11‐nor‐9carboxy‐Δ 9 ‐tetrahydrocannabinol (THC‐COOH), and 11‐nor‐9carboxy‐Δ 9 ‐tetrahydrocannabinol glucuronide (THC‐COOH‐GLU) were purchased from Lipomed (Arlesheim, Switzerland).
Techniques: Dispersion, Injection